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pentobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these drugs lower exposure to vandetanib by nearly forty%.pentobarbital will minimize the extent or result of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4